93630-93-4

Upstream product

• 716-43-8 dimethyl homophthalate 
• 93630-92-3 1-Methyl-3-(toluene-4-sulfonyl)-3,4,5,6-tetrahydro-pyrimidin-1-ium; iodide 
• 131-11-3 phthalic acid dimethyl ester 

Downstream Products

• 102728-63-2 14-(methoxycarbonyl)-1-tosyl-21-oxo-Δ15,17,19-yohimbane 
• 93630-98-9 methyl-α-<1-(1,2,3,4-tetrahydro-β-carbonyl)>-2-methoxycarbonyl-1-phenylacetate 
• 383148-69-4 2-[2-(1H-Indol-3-yl)-ethyl]-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid methyl ester 
• 93630-96-7 2-methoxycarbonyl-α-(methoxycarbonyl)-β-tryptaminyl-styrene 
• 93630-97-8 2-methoxycarbonyl-α-(methoxycarbonyl)-β-tryptaminyl-styrene 

Relevant academic research and scientific papers

Models of folate coenzymes 141 1 Part 13. A.R. Stoit and U.K. Pandit, Tetrahedron, preceding paper. An alternate approach to the yohimbane skeleton

The anion of dimethyl homophthalate adds to imidazolinium and tetrahydropyrimidinium salts (2a,b) to yield imidazolidine and tetrahydropyrimidine adducts corresponding to methylenetetra-hydrofolate models (3a,b). These models transfer the carbon fragment

β-AMINOSTYRYL DERIVATIVES VIA FOLATE MODELS. APPROACH TO YOHIMBANE SKELETON

2-Methoxycarbonyl-(α-methoxycarbonyl-β-tryptaminyl)styrene, prepared by transfer of CH3OOC-2-C6H4CH(COOCH3)CH= via a methylenetetrahydrofolate model, to tryptamine, yields the pentacyclic system of yohimbane in two steps.