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Pentanedioic acid, 2-methylene-, 5-methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

93633-32-0

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93633-32-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 93633-32-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,6,3 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 93633-32:
(7*9)+(6*3)+(5*6)+(4*3)+(3*3)+(2*3)+(1*2)=140
140 % 10 = 0
So 93633-32-0 is a valid CAS Registry Number.

93633-32-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methoxy-2-methylidene-5-oxopentanoate

1.2 Other means of identification

Product number -
Other names 2-methylene-pentanedionate-5-methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:93633-32-0 SDS

93633-32-0Relevant articles and documents

Lactam-based HDAC inhibitors for anticancer chemotherapy: Restoration of RUNX3 by posttranslational modification and epigenetic control

Cho, Misun,Choi, Eunhyun,Kim, Jae Hyun,Kim, Hwan,Kim, Hwan Mook,Lee, Jang Ik,Hwang, Ki-Chul,Kim, Hyun-Jung,Han, Gyoonhee

supporting information, p. 649 - 656 (2014/03/21)

Expression and stability of the tumor suppressor runt-related transcription factora 3 (RUNX3) are regulated by histone deacetylase (HDAC). HDAC inhibition alters epigenetic and posttranslational stability of RUNX3, leading to tumor suppression. However, HDAC inhibitors can nonselectively alter global gene expression through chromatin remodeling. Thus, lactam-based HDAC inhibitors were screened to identify potent protein stabilizers that maintain RUNX3 stability by acetylation. RUNX activity and HDAC inhibition were determined for 111 lactam-based analogues through a cell-based RUNX activation and HDAC inhibition assay. 3-[1-(4-Bromobenzyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-N- hydroxypropanamide (11-8) significantly increased RUNX3 acetylation and stability with relatively low RUNX3 mRNA expression and HDAC inhibitory activity. This compound showed significant antitumor effects, which were stronger than SAHA, in an MKN28 xenograft model. Thus, we propose a novel strategy, in which HDAC inhibitors serve as antitumor chemotherapeutic agents that selectively target epigenetic regulation and protein stability of RUNX3.

A catalytic approach to the MH-031 lactone: Application to the synthesis of geralcin analogs

Tello-Aburto, Rodolfo,Lucero, Alyssa N.,Rogelj, Snezna

, p. 6266 - 6268 (2014/12/11)

A concise, 5-step synthesis of the hepatoprotective lactone MH-031 was achieved. Our approach utilizes several catalytic processes, namely, a Rauhut-Currier reaction, a chemoselective Fisher esterification, and a ring closing metathesis. Further elaboration of this lactone yielded the hydrazide natural product geralcin A and dihydrogeralcin B, a saturated analog of geralcin B. Biological evaluation of the latter indicated that the presence of the enehydrazide moiety in geralcin B is critical for anticancer activity.

Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel δ-lactam-based histone deacetylase (HDAC) inhibitors

Kim, Hwan Mook,Lee, Kiho,Park, Bum Woo,Ryu, Dong Kyu,Kim, Kangjeon,Lee, Chang Woo,Park, Song-Kyu,Han, Jung Whan,Lee, Hee Yoon,Lee, Hyun Yong,Han, Gyoonhee

, p. 4068 - 4070 (2007/10/03)

δ-Lactam-based hydroxamic acids, inhibitors of histone deacetylase (HDAC), have been synthesized via ring closure metathesis of key diene intermediates followed by conversion to hydroxamic acid analogues. The hydroxamic acids 12a, 12b, and 17c showed potent inhibitory activity in HDAC enzyme assay. The hydroxamic acid 12b exhibited growth inhibitory activity on five human tumor cell lines, showing good sensitivity on the MDA-MB-231 breast tumor cell.

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