936336-91-3

Upstream product

• 67853-03-6 methyl 3-(hydroxymethyl)benzoate 
• 1877-71-0 benzene 1,3-dicarboxylic acid monomethyl ester 
• 936336-90-2 methyl 3-(triisopropylsilanyloxymethyl)benzoate 
• 313279-13-9 (3-triisopropylsilyloxymethylphenyl)methanol 

Downstream Products

• 936336-92-4 (3-iodomethylbenzyloxy)-triisopropylsilane 
• 1418713-76-4 2-(3-(((triisopropylsilyl)oxy)methyl)phenyl)acetic acid 
• 936336-95-7 3-(dimethylsulfamoyl-3H-imidazol-4-ylmethyl)-benzoic acid 
• 936336-96-8 C₁₃H₁₅O₃N₃S 
• 936336-94-6 (N,N-dimethyl)-[5-(3-hydroxymethylbenzyl)-imidazole]-1-sulfonamide 
• 936336-93-5 (N,N-dimethyl)-[2-triisopropylsilanyl-5-(3-triisopropylsilanyloxymethylbenzyl)-imidazole]-1-sulfonamide 

Relevant academic research and scientific papers

Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor

Four tripeptides corresponding to the C-terminal region of angiotensin II were synthesized. One of these peptides (Ac-His-Pro-Ile) showed moderate binding affinity for the AT2 receptor. Two aromatic histidine-related scaffolds were synthesized and introduced in the tripeptides to give eight new peptidomimetic structures. Three of the new peptide-derived druglike molecules exhibited selective, nanomolar affinity for the AT2 receptor. These ligands may become lead compounds in the future development of novel classes of selective AT2 receptor agonists.