936367-72-5

Upstream product

• 452-77-7 3-fluoro-4-methyl-phenylamine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1072827-28-1 (S)-3-(3-fluoro-4-methyl-phenyl)-5-hydroxymethyl-oxazolidin-2-one 
• 1072792-43-8 (R)-5-aminomethyl-3-(3-fluoro-4-methyl-phenyl)-oxazolidin-2-one 
• 1072828-18-2 [(R)-3-(3-fluoro-4-methyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

OXAZOLIDINYL ANTIBIOTICS

The invention relates to antibacterial compounds of Formula (I) wherein R1 is alkoxy or halogen; U and V each independently are CH or N; ---- is a bond or is absent; W is CH or N or, when ---- is absent, W is CH2 or NH, with the proviso that U, V and W are not all N; A is a bond or CH2; R2 is H or, provided A is CH2, may also be OH; m and n each independently are 0 or 1; D is CH2 or a bond; G represents a phenyl group substituted once or twice in the meta and/or para position (s) by substituents selected from alkyl, (C1-C3)akyl and halogen, or G is a group G1 or G2 wherein Z1, Z2 and Z3 may each represent CH or N; X is N or CH and Q is 0 or S; it being understood that if m and n each are 0, then A is CH2; and salts of such compounds

TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS

The invention relates to antibacterial compounds of formula (I) wherein “-----” is a bond or is absent, V is CH, CR 6 or N; R 0 is H or, if “-----” is a bond, may also be alkoxy; R 1 is notably H or halogen; U is CH or N when “-----” is a bond, or, if “-----” is absent, U is CH 2, NH or NR 9; R 2 is H, alkylcarbonyl or –CH 2 -R 3; R 3 is H, alkyl or hydroxyalkyl; R 4 is H or, if n is not 0 and R 5 is H, may also be OH; R 5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R 6 is hydroxyalkyl, carboxy, alkoxycarbonyl or -(CH 2 ) q -NR 7 R 8, q being 1, 2 or 3 and each of R 7 and R 8 independently being H or alkyl or R 7 and R 8 forming with the N atom bearing them a ring; R 9 is alkyl or hydroxyalkyl; A is -(CH 2 ) p -, -CH 2 CH 2 CH(OH)- or -COCH 2 CH(OH)-; G is substituted phenyl or G 1 or G 2, wherein Q is O or S and X is CH or N; and Y 1, Y 2 and Y 3 may each be CH or N; and n is 0 when A is -CH 2 CH 2 CH(OH)- or -COCH 2 CH(OH)-, and n is 0, 1 or 2 when A is -(CH 2 ) p -, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts of such compounds.