936372-38-2Relevant academic research and scientific papers
Asymmetric hydrogenation of ketones with ruthenium complexes of rac- and enantiopure (S,S)-1,2-bis((diphenylphosphino)methyl)cyclohexane: A comparative study with rac- and (R)-BINAP
Doherty, Simon,Knight, Julian G.,Bell, Adam L.,Harrington, Ross W.,Clegg, William
, p. 2465 - 2468 (2007)
Ruthenium(II) complexes of the type trans-[RuCl2-{1,2- bis((diphenylphosphino)methyl)cyclohexane}(diamine)]based on the inexpensive and easy-to-prepare rac- and (S,S)-1,2-bis-((diphenylphosphino)methyl) cyclohexaneform highly active and enantioselective catalysts for the asymmetric hydrogenation of a wide range of aryl and heteroaryl ketones, in most cases giving ee's that exceed those obtained with their BINAP counterparts. Although precatalysts based on 1,2-bis((diphenylphosphino)-methyl)cyclohexane slowly isomerize in solution to afford the thermodynamically favored isomer with a cis arrangement of chlorides, catalysts generated from both isomers afford similar enantioselectivities.
