936474-09-8

Basic information

• Product Name: 1-Aminoindan sulfate (Rasagiline)
• Synonyms: 1-Aminoindan sulfate (Rasagiline);1-Aminoindan sulfate;2,3-Dihydro-1H-inden-1-amine sulfate
• CAS NO: 936474-09-8
• Molecular Formula: 2(C9H11N).H2SO4
• Molecular Weight: 364.46
• Product Categories: APIs Intermediate
• Mol File: 936474-09-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Aminoindan sulfate (Rasagiline)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminoindan sulfate (Rasagiline)(936474-09-8)
• EPA Substance Registry System: 1-Aminoindan sulfate (Rasagiline)(936474-09-8)

Safety Data

• Hazardous Substances Data: 936474-09-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Aminoindan sulfate (Rasagiline) is used as a therapeutic agent for the treatment of Parkinson's disease. It is utilized to improve motor symptoms and reduce the risk of complications associated with the condition.
1-Aminoindan sulfate (Rasagiline) is used as a long-term treatment for Parkinson's disease to enhance the quality of life for patients by managing the disease's progression and mitigating its symptoms.
Additionally, it may be used to treat other conditions as determined by a healthcare provider, depending on its potential applications and efficacy in those areas. Common side effects of rasagiline include headache, joint pain, and stomach upset, and it is crucial to adhere to the dosage and administration instructions provided by a healthcare professional.

InChI:InChI=1/C9H11N.H2O4S/c10-9-6-5-7-3-1-2-4-8(7)9;1-5(2,3)4/h1-4,9H,5-6,10H2;(H2,1,2,3,4)

Upstream product

• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 7664-93-9 sulfuric acid 

Relevant articles and documents

Dynamic power learning split preparation (S)- 1 - amino indane

The invention relates to a preparation method of optically pure (S)-1-aminoindane. The preparation method comprises steps as follows: 1-aminoindane is taken as a raw material, a solvent, Candida rugose lipase, an acyl donor L-(+)-O-acetyl mandelic acid and a racemization catalyst KT-02 are added to a high pressure kettle in proportion, hydrogen is introduced, all components react for a period of time, and then 1-aminoindane can be completely converted into an acetyl compound of (S)-1-aminoindane. A product is purified and subjected to acid hydrolysis and alkali free operation, (S)-1-aminoindane is obtained, and an ee value of a final product is larger than 99%. The preparation method has the characteristics that the operation is simple, the racemization catalyst is cheap and available, the raw material is completely utilized, the optical purity of the product is high and the like; the preparation method has great guidance and application value in the aspect of production and preparation of (S)-1-aminoindane.

Methods for isolating propargylated aminoindans

Disclosed is a process for isolating from a reaction mixture a salt of a mono-propargylated aminoindan having the structure wherein R1 is H, hydroxyl, alkoxy or wherein Y is O or S; R2 and R3 is each, independently, C1-8 alkyl, C6-12 aryl, C6-12 aralkyl, each optionally halo substituted, or hydrogen; where the reaction mixture further comprises a solvent, a primary aminoindan having the structure wherein R1 is defined as above, and a tertiary aminoindan having the structure the process comprising d) adding an acid to the reaction mixture; e) crystallizing the mono-propargylated aminoindan under conditions suitable for the formation of a crystalline salt of the mono-propargylated aminoindan; and f) recovering the crystalline salt of the mono-propargylated aminoindan, wherein the process is performed without addition of an organic solvent. Also disclosed are the crystalline diastereomeric salts produced by the process and pharmaceutical compositions containing the salts.