936476-25-4

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 2458-26-6 3-phenylpyrazole 

Downstream Products

• 1240795-90-7 2-bis(3-phenylpyrazol-1-yl)methylphenol 
• 936476-38-9 C₂₃H₂₄N₄S₂ 
• 936476-23-2 2-methyl-1,1-bis-(3-phenyl-pyrazol-1-yl)-propane-2-thiol 
• 936476-26-5 C(CH₃)2SCH₃CH(C₃H₂N₂(C₆H₅))2 

Relevant academic research and scientific papers

Metal-free, Mild, and Selective Synthesis of Bis(pyrazolyl)alkanes by Nucleophile-Catalyzed Condensation

Bis(pyrazolyl)alkanes are a prolific class of ligands for catalysis, accessible by the condensation between bis(pyrazolyl)methanones and carbonyls. In this report, we describe a nucleophile-catalyzed innovation on this condensation that avoids the transition metals, high temperatures, reagent excess, and air-sensitive reagents common among the existing protocols. Significantly, this method accommodates sterically hindered and electronically diverse pyrazoles and aldehydes, applicable for systematic ligand optimization. Furthermore, our scope includes azoles and bridging functional groups previously unreported for this reaction, promising for new heteroscorpionate catalysts. We provide the first direct evidence for an elusive reaction intermediate and characterize the most complete mechanism for this condensation.

Modeling the inhibition of peptide deformylase by hydroxamic acids: Influence of the sulfur donor

The first complexes containing both a sulfur atom and a hydroxamate moiety coordinated to a biologically relevant transition metal were synthesized as models for the structure of inhibited peptide deformylases. Two of these [(N2S)Zn(hydroxamate