93648-83-0Relevant articles and documents
Microwave-enhanced Goldberg reaction: A novel route to N-arylpiperazinones and N-arylpiperazinediones
Lange, Jos H.M,Hofmeyer, Lovina J.F,Hout, Floris A.S,Osnabrug, Stefan J.M,Verveer, Peter C,Kruse, Chris G,Feenstra, Rolf W
, p. 1101 - 1104 (2002)
An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reaction using NMP as solvent. Alkylation at the 3-position of the formed N-aryl-2-piperazinones furnishes new N-aryl-3-alkyl-2-piperazinones.
