93648-83-0Relevant academic research and scientific papers
Microwave-enhanced Goldberg reaction: A novel route to N-arylpiperazinones and N-arylpiperazinediones
Lange, Jos H.M,Hofmeyer, Lovina J.F,Hout, Floris A.S,Osnabrug, Stefan J.M,Verveer, Peter C,Kruse, Chris G,Feenstra, Rolf W
, p. 1101 - 1104 (2002)
An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reaction using NMP as solvent. Alkylation at the 3-position of the formed N-aryl-2-piperazinones furnishes new N-aryl-3-alkyl-2-piperazinones.
Heterocyclic derivatives as modulators of ion channels
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Page/Page column 278, (2010/11/29)
The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
