936487-52-4

Upstream product

• 623547-28-4 2-chloro-5-(methoxymethyleneamino)-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylidene-β-D-ribofuranosyl]imidazole-4-nitrile 
• 936487-51-3 8-chloro-N-1-[(1R,2R,4S)-2-methoxymethyloxy-4-(hydroxymethyl)cyclopentyl]-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine 
• 859147-46-9 (1R,2R,4R)-1-amino-2-(methoxymethyloxy)-4-hydroxymethylcyclopentane 

Downstream Products

• 936487-53-5 8-chloro-N-1-[(1R,2R,4S)-2-methoxymethyloxy-4-(4,4'-dimethoxytrityloxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine 
• 936487-54-6 8-chloro-N-1-[(1R,2R,4S)-2-methoxymethyloxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine 

Relevant academic research and scientific papers

Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1

We previously showed that 3″-deoxy-cyclic ADP-carbocyclic-ribose (3″-deoxy-cADPcR, 4) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger. From these results, we designed and synthesized ot