936494-89-2Relevant academic research and scientific papers
Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities
Ojika, Makoto,Kigoshi, Hideo,Yoshida, Yoshifumi,Ishigaki, Takeshi,Nisiwaki, Masanori,Tsukada, Itaru,Arakawa, Masayuki,Ekimoto, Hisao,Yamada, Kiyoyuki
, p. 3138 - 3167 (2007/10/03)
Aplyronine A (2), a potent antitumor macrolide was isolated from the sea hare Aplysia kurodai together with the congeners aplyronines B (3) and C (4). The absolute stereostructure of aplyronine A (2) was determined by the instrumental analysis (mainly NMR and MS) and the enantioselective synthesis of the fragments obtained from chemical degradation of aplyronine A (2). The structures of aplyronines B (3) and C (4) were also elucidated. Cytotoxicity and antitumor activity of aplyronine A (2) were evaluated.
Futher Studies on Aplyronine A, an Antitumor Substance Isolated from the Sea Hare Aplysia kurodai
Ojika, Makoto,Kigoshi, Hideo,Ishigaki, Takeshi,Yamada, Kiyoyuki
, p. 8501 - 8504 (2007/10/02)
By a series of reactions aplyronine A (1) an antitumor substance of marine origin was transformed into six fragments, and their structures were characterized by spectroscopic methods.Relative stereochemistry of four contiguous chiral centers (C29-C32) in 1 was established and that of three contiguous chiral centers (C23-C25) in 1 was deduced on the basis of the 1H NMR spectral analysis of the fragment 8 and the derived acetonide 9, respectively.
