936539-81-0

Basic information

• Product Name: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride
• Synonyms: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride
• CAS NO: 936539-81-0
• Molecular Formula: C₂₁H₁₅ClN₄O₃*ClH
• Molecular Weight: 443.28274
• Product Categories: Betrixaban
• Mol File: 936539-81-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride(936539-81-0)
• EPA Substance Registry System: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride(936539-81-0)

Safety Data

• Hazardous Substances Data: 936539-81-0(Hazardous Substances Data)

Usage

General Description

N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride is a chemical compound that acts as an inhibitor of the protein tyrosine kinase c-Met. It is used in the research and development of potential anticancer drugs due to its ability to block the activity of c-Met, which is involved in the progression and spread of various types of cancer. N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride is a hydrochloride salt, making it more water-soluble and easily dissolvable in aqueous solutions, which is valuable for laboratory experiments and drug formulation. Its structure includes a pyridine ring, a cyanobenzoyl group, and a methoxybenzamide moiety, all of which contribute to its biological activity and potential therapeutic applications. Overall, N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide hydrochloride is a promising chemical compound with implications for cancer research and drug development.

Upstream product

• 280773-17-3 2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide 
• 619-65-8 4-cyanobenzoic Acid 
• 330942-01-3 N-(5-chloro(2-pyridyl)){2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}carboxamide 
• 6068-72-0 4-cyanobenzoyl chlorIde 

Downstream Products

• 330942-05-7 betrixaban 

Relevant articles and documents

Preparation method of betrixaban intermediate and betrixaban and product thereof

The invention relates to a preparation method of a betrixaban intermediate or salt thereof. The method includes: under the action of a catalyst, adding an amide coupling reagent dropwise into a compound shown as formula SM-III and a compound shown as formula SM-I or salts thereof for condensation reaction in an organic solvent to form a compound shown as formula III or a salt thereof, and furtherpreparing the betrixaban intermediate or the salt thereof into betrixaban or a salt thereof. The betrixaban or the hydrochloride thereof prepared by the method provided by the invention basically doesnot contain dechlorinated impurity V or demethylated impurity VI, and has high purity. The method improves the product yield, reduces the use of high corrosive raw materials, is low in cost, and is suitable for industrial production.

METHODS OF SYNTHESIZING PHARMACEUTICAL SALTS OF A FACTOR XA INHIBITOR

Novel methods of preparing a compound of Formula I which is an inhibitor of Factor Xa and its maleate salt, are described herein.

Novel pharmaceutical salts and polymorphs of a factor Xa inhibitor

The present invention provides for salts comprising a compound of Formula I and an acid that has activity against mammalian factor Xa. The present invention is also directed to methods of making the compound of Formula I.