936563-51-8

Basic information

• Product Name: 3-(3,4-dimethoxy-benzyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester
• Synonyms: 3-(3,4-dimethoxy-benzyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester
• CAS NO: 936563-51-8
• Molecular Weight: 328.365
• Mol File: 936563-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dimethoxy-benzyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxy-benzyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester(936563-51-8)
• EPA Substance Registry System: 3-(3,4-dimethoxy-benzyl)-2,3-dihydro-benzofuran-3-carboxylic acid methyl ester(936563-51-8)

Safety Data

• Hazardous Substances Data: 936563-51-8(Hazardous Substances Data)

Upstream product

• 533-58-4 2-Iodophenol 
• 4224-69-5 methyl 2-(bromomethyl)propenoate 
• 936563-48-3 2-(2-(methoxycarbonyl)allyloxy)-iodobenzene 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 

Relevant articles and documents

Efficient synthetic approach to heterocycles possessing the 3,3-disubstituted-2,3-dihydrobenzofuran skeleton via diverse palladium-catalyzed tandem reactions

Various palladium-catalyzed cascade reactions of O-alkylated 2-iodophenol were explored in order to synthesize novel dihydrobenzofurans. An efficient tandem cyclization/anion capture reaction was developed to yield 3,3-disubstituted-2,3-dihydrobenzofurans. A small library of these compounds was prepared with a parallel organic synthesizer. A multi-component version of this reaction involving 2-iodophenol, an alkylating agent and a nucleophile, provided the same products. The methoxycarbonyl-substituted heterocyclic ring was hydrolyzed to a free acid, which could be used for further transformations.