936632-68-7

Basic information

• Product Name: 1-deoxy-1-(6-{4-[(4-chlorophenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide
• Synonyms: 1-deoxy-1-(6-{4-[(4-chlorophenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide
• CAS NO: 936632-68-7
• Molecular Weight: 608.053
• Mol File: 936632-68-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-deoxy-1-(6-{4-[(4-chlorophenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-deoxy-1-(6-{4-[(4-chlorophenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide(936632-68-7)
• EPA Substance Registry System: 1-deoxy-1-(6-{4-[(4-chlorophenylcarbamoyl)methoxy]phenylamino}-9H-purin-9-yl)-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide(936632-68-7)

Safety Data

• Hazardous Substances Data: 936632-68-7(Hazardous Substances Data)

Upstream product

• 3289-75-6 2-chloro-N-(4-chlorophenyl)acetamide 
• 881607-14-3 2-(4-aminophenoxy)-N-(4-chlorophenyl)acetamide 
• 924281-79-8 1-deoxy-1-(6-iodo-9H-purin-9-yl)-2,3-O-isopropylidene-N-ethyl-β-D-ribofuranuronamide 
• 106-47-8 4-chloro-aniline 
• 20916-22-7 N-(4-chlorophenyl)-2-(4-nitrophenoxy)acetamide 

Relevant articles and documents

N6-[(Hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A2B adenosine receptor

A new series of N6-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines (24-43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl)-methoxy]-phenyl chain at the N6 position of 5′-N-ethylcarboxamido-adenosine led us to the recognition of compound 24 as a full agonist displaying the highest efficacy of the series (EC50 hA2B = 7.3 nM). These compounds represent the first report about adenosine-related structures capable of activating hA2B subtype in the low nanomolar range.