936691-41-7

Upstream product

• 936691-36-0 2-((1R,3R)-1-acetoxy-3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentyl)thiazole-4-carboxylic acid 
• 936691-40-6 C₁₅H₂₁NO₂ 
• 112121-72-9 Methyl (R)-(-)-N-benzyloxycarbonylamino-4-methylpentanoate 
• 108-24-7 acetic anhydride 
• 107-18-6 allyl alcohol 
• 13734-41-3 t-Boc-L-valine 
• 45170-31-8 Boc-N-Me-Val-OH 
• 936691-37-1 [1-benzyl-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 221205-03-4 [(R)-1-(2-Hydroxy-ethyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 90105-46-7 benzyl (S)-(1-diazo-4-methyl-2-oxopentan-3-yl)carbamate 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 936691-29-1 tert-butyl (R)-(1-hydroxy-4-methylpentan-3-yl)(methyl)carbamate 
• 936691-28-0 benzyl (R)-1-hydroxy-4-methylpentan-3-yl(methyl)carbamate 
• 936691-27-9 C₂₁H₃₇O₃NSi 

Downstream Products

• 936691-42-8 (2S,4R)-allyl 4-(2-((1R,3R)-1-acetoxy-4-methyl-3-(methylamino)pentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 
• 936691-43-9 allyl (2S,4R)-4-(2-((5S,8R,10R)-5-sec-butyl-1-(9H-fluoren-9-yl)-8-isopropyl-7-methyl-3,6,12-trioxo-2,11-dioxa-4,7-diazatridecan-10-yl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 
• 936691-44-0 (2S,4R)-allyl 4-(2-((1R,3R)-1-acetoxy-3-((2S,3S)-2-amino-N,3-dimethylpentanamido)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 
• 936691-45-1 (2S,4R)-allyl 4-(2-((1R,3R)-1-acetoxy-3-((2S,3S)-N,3-dimethyl-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)-4-methylpentyl)thiazole-4-carboxamido)-2-methyl-5-phenylpentanoate 

Relevant academic research and scientific papers

TARGETED DELIVERY OF TERTIARY AMINE-CONTAINING DRUG SUBSTANCES

Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.

Total Synthesis and Biological Evaluation of Tubulysin Analogues

We report a second-generation synthesis of the exceedingly potent antimitotic agent N14-desacetoxytubulysin H (1) as well as the preparation of nine analogues of this lead structure. Highlights of our synthetic efforts include an efficient late

Total synthesis of N14-desacetoxytubulysin H

Equation presented The N14-desacetoxy analogue of tubulysin H was prepared in 20 steps and 2.1% overall yield. Our strategy features a thiazole anion addition to assemble the tubuvaline residue at the C(10)-C(11) bond, as well as acylations at