936699-54-6

Basic information

• Product Name: tert-butyl (R)-3-(4-methylphenyl)-3-hydroxypropanoate
• Synonyms: tert-butyl (R)-3-(4-methylphenyl)-3-hydroxypropanoate
• CAS NO: 936699-54-6
• Molecular Weight: 236.311
• Mol File: 936699-54-6.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-3-(4-methylphenyl)-3-hydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-3-(4-methylphenyl)-3-hydroxypropanoate(936699-54-6)
• EPA Substance Registry System: tert-butyl (R)-3-(4-methylphenyl)-3-hydroxypropanoate(936699-54-6)

Safety Data

• Hazardous Substances Data: 936699-54-6(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 104-87-0 4-methyl-benzaldehyde 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 

Relevant articles and documents

(R)-(+)-N-Methylbenzoguanidine ((R)-NMBG) catalyzed acylative kinetic resolution of racemic 3-hydroxy-3-aryl-propanoates

(R)-(+)-N-methylbenzoguanidine ((R)-NMBG) functioned as an efficient acyl transfer catalyst for the acylative kinetic resolution of racemic β-hydroxy esters using cyclohexane carboxylic anhydride under mild reaction conditions. A tert-butyl ester moiety is necessary to achieve a high selectivity. The effects of the substituents on the aromatic rings of the substrates were systematically investigated, and diverse substrates participated in the reaction with good s-values (>20) irrespective of the type of substituents and their patterns, except for o-methoxy group.

Asymmetric dehydration of β-hydroxy esters and application to the syntheses of flavane derivatives

Catalytic asymmetric dehydration of β-aryl or alkyl substituted β-hydroxy esters via kinetic resolution has been investigated. A brief survey of 10 different chiral ligands is conducted to examine the effects of chiral ligand structure on selectivity of t

Asymmetric dehydration of β-hydroxy esters via kinetic resolution

Catalytic asymmetric dehydration of β-hydroxy esters via kinetic resolution has been investigated. The kinetic resolution of rac-β-hydroxy esters in the presence of prolinol chiral ligand 2a and BrZnCH2CO2t-Bu can provide highly enan

D-Phg-L-Pro Dipeptide-derived prolinol ligands for highly enantioselective Reformatsky reactions

Optically pure N-aminoethyl prolinol derivatives 3a-c have been prepared from the dynamic kinetic resolution of N-(α-bromo-α-phenylacetyl) proline ester 1 in asymmetric nucleophilic substitution and subsequent reduction. The peptide-derived prolinols are