93674-34-1

Upstream product

• 1734-79-8 3-(4-nitrophenyl)-2-propenal 
• 62-53-3 aniline 

Downstream Products

• 1203703-34-7 (Z)-2-benzylidene-4-(4-nitrophenyl)-1-phenyl-3-tosyl-1,2,3,4-tetrahydropyrimidine 
• 1609262-53-4 10-(4-nitrobenzyl)-4-oxo-1-phenyl-1,4-dihydropyrimido[1,2-a]indole-3-carboxylic acid methyl ester 
• 1609262-35-2 1-(2-bromophenyl)-2-[2-(4-nitrophenyl)vinyl]-6-oxo-3-phenyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid dimethyl ester 
• 1609261-95-1 1-(4-bromophenyl)-2-[2-(4-nitrophenyl)vinyl]-6-oxo-3-phenyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

N-heterocyclic carbene and Bronsted acid cooperative catalysis: Asymmetric synthesis of trans -γ-Lactams

An efficient enantioselective approach to form trans-γ-lactams in up to 99% yield, 93% ee, and >20/1 dr using unactivated imines has been developed. The cyclohexyl-substituted azolium and the weak base sodium o-chlorobenzoate are most suitable for this tr

Synthesis of β-Phosphinolactams from Phosphenes and Imines

Various cis-β-phosphinolactams are synthesized stereoselectively for the first time from imines and diazo(aryl)methyl(diaryl)phosphine oxides under microwave irradiation. Diazo(aryl)methyl(diaryl)phosphine oxides first undergo the Wolf rearrangement to generate phosphenes. Imines nucleophilically attack the phosphenes followed by an intramolecular nucleophilic addition via less steric transition states to give final cis-β-phosphinolactams. C-Styrylimines generally give rise to β-phosphinolactams in higher yields than C-arylimines. The stereoselectivity and proposed mechanism are rationalized by DFT theoretical calculation.