93677-66-8

Basic information

• Product Name: 6-oxaundeca-2,10-dione
• Synonyms: 6-oxaundeca-2,10-dione
• CAS NO: 93677-66-8
• Molecular Weight: 186.251
• Mol File: 93677-66-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-oxaundeca-2,10-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-oxaundeca-2,10-dione(93677-66-8)
• EPA Substance Registry System: 6-oxaundeca-2,10-dione(93677-66-8)

Safety Data

• Hazardous Substances Data: 93677-66-8(Hazardous Substances Data)

Upstream product

• 1071-73-4 5-Hydroxy-2-pentanone 
• 765-43-5 Cyclopropyl methyl ketone 

Relevant articles and documents

Continuous-Flow Multistep Synthesis of Cinnarizine, Cyclizine, and a Buclizine Derivative from Bulk Alcohols

Cinnarizine, cyclizine, buclizine, and meclizine belong to a family of antihistamines that resemble each other in terms of a 1-diphenylmethylpiperazine moiety. We present the development of a four-step continuous process to generate the final antihistamines from bulk alcohols as the starting compounds. HCl is used to synthesize the intermediate chlorides in a short reaction time and excellent yields. This methodology offers an excellent way to synthesize intermediates to be used in drug synthesis. Inline separation allows the collection of pure products and their immediate consumption in the following steps. Overall isolated yields for cinnarizine, cyclizine, and a buclizine derivative are 82, 94, and 87 %, respectively. The total residence time for the four steps is 90 min with a productivity of 2 mmol h-1. The incredible bulk: Bulk alcohols are converted continuously into chlorides using HCl in a microflow. A reaction network that consists of four steps and two inline separations leads to the continuous preparation of cinnarizine, cyclizine, and a buclizine derivative with yields of 82, 94, and 87 %, respectively. The total residence time for the four steps is 90 min with a productivity of 2 mmol h-1.