936835-79-9Relevant academic research and scientific papers
Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore
Balboni, Gianfranco,Onnis, Valentina,Congiu, Cenzo,Zotti, Margherita,Sasaki, Yusuke,Ambo, Akihiro,Bryant, Sharon D.,Jinsmaa, Yunden,Lazarus, Lawrence H.,Lazzari, Ilaria,Trapella, Claudio,Salvadori, Severo
, p. 3143 - 3151 (2008/02/07)
A wide range of activities are induced by Lys when introduced at C-terminus of the δ-opioid Dmt-Tic pharmacophore through the α-amine group, including: improved δ-antagonism, μ-agonism and μ-antagonism. Here we report the synthesis of a new series of comp
