936846-02-5

Basic information

• Product Name: 4-(6-{5-[2-(1-benzoyl-1H-indazol-5-yl)-vinyl]-thiazol-2-ylamino}-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(6-{5-[2-(1-benzoyl-1H-indazol-5-yl)-vinyl]-thiazol-2-ylamino}-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 936846-02-5
• Molecular Weight: 622.751
• Mol File: 936846-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(6-{5-[2-(1-benzoyl-1H-indazol-5-yl)-vinyl]-thiazol-2-ylamino}-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-{5-[2-(1-benzoyl-1H-indazol-5-yl)-vinyl]-thiazol-2-ylamino}-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester(936846-02-5)
• EPA Substance Registry System: 4-(6-{5-[2-(1-benzoyl-1H-indazol-5-yl)-vinyl]-thiazol-2-ylamino}-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester(936846-02-5)

Safety Data

• Hazardous Substances Data: 936846-02-5(Hazardous Substances Data)

Upstream product

• 936846-01-4 (5-bromo-indazol-1-yl)-phenyl-methanone 
• 936845-86-2 4-[2-methyl-6-(5-vinyl-thiazol-2-ylamino)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

THIAZOLE INHIBITORS TARGETING RESISTANT AND KINASE MUTATIONS

A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophobic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.