936846-17-2Relevant academic research and scientific papers
Of escitalopram oxalate-related substance and its preparation method
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Paragraph 0035; 0036, (2018/12/13)
The invention relates to an escitalopram oxalate related substance and a preparation method thereof, and particularly, relates to the related substance of an antidepressant drug, the escitalopram oxalate (namely, (S)-(+)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-formonitrile oxalate), represented as the formula (I) and a preparation method thereof. The escitalopram oxalate, as the target compound, is synthesized through reactions comprising hydrolysis, acylation, condensation, reduction, addition and oxidization to the compound (II) (namely, (S)-(+)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-formonitrile). According to the method, the compound (I) is chemically synthesized for the first time. By means of the method, the target compound can be obtained through high-efficient and quick separation.
Novel and high affinity fluorescent ligands for the serotonin transporter based on (S)-citalopram
Kumar, Vivek,Rahbek-Clemmensen, Troels,Billesb?lle, Christian B.,Jorgensen, Trine Nygaard,Gether, Ulrik,Newman, Amy Hauck
supporting information, p. 696 - 699 (2014/07/07)
Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently
