936850-87-2

Upstream product

• 714-14-7 benzyloxycarbonylthioacetamide 
• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 79878-57-2 2-ethoxycarbonylmethyl-4-hydroxythiazole 

Downstream Products

• 1257397-90-2 ethyl 2-(5-(hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)acetate 

Relevant academic research and scientific papers

CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE

Compounds that modulate gamma secretase (e.g., alter the cleavage pattern of gamma secretase) are described herein. Also disclosed are pharmaceutical compositions, methods of modulating the activity of gamma secretase, and methods of treating Alzheimer's Disease using the compounds described herein.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.