936945-09-4

Basic information

• Product Name: 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate
• Synonyms: 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate
• CAS NO: 936945-09-4
• Molecular Formula: C20H24F3NO12S
• Molecular Weight: 559.4642696
• Product Categories: Amines;Aromatics;Carbohydrates & Derivatives;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 936945-09-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Methanol, Water
• CAS DataBase Reference: 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate(936945-09-4)
• EPA Substance Registry System: 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate(936945-09-4)

Safety Data

• Hazardous Substances Data: 936945-09-4(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Liquid

Uses

3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridiniuM Triflate is used in the synthesis of Nicotinamide Ribose (N407770) and its derivatives.

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 13035-61-5 1,2,3,5-tetraacetylribose 

Relevant articles and documents

Β - nicotinamide mononucleotide preparation method

The invention discloses a preparation method of β - nicotinamide mononucleotide. The preparation method of β - nicotinamide mononucleotide comprises the following steps: S1: in the presence of first solvent and catalyst, nicotinate and tetraacetyl - D - ribose undergo condensation reaction in first microchannel reactor to obtain the material A. The temperature of the condensation reaction is 51 - 80 °C, and the residence time of the condensation reaction is 0.5 - 10 min. S2: Material A Removal first of the solvent gives material B. S3: In the presence of second solvent, the material B and the liquid ammonia are subjected to an ammonolysis reaction to obtain the material C. S4: The mixture of material C and third solvent removed second solvent and unreacted liquid ammonia to give material D. S5: The material D phosphorylates and reacts with the phosphorylation auxiliary to obtain. The β - nicotinamide mononucleotide preparation method can effectively shorten the reaction time, improve the production efficiency, lower the side reaction and improve the product yield.

The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

Haemophilus influenzae is a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NAD(P) for its nicotinamide dinucleotide requirement. This strategy is organized around a periplasmic enzyme termed NadN (NAD n