93696-63-0

Usage

Type of compound

Synthetic organic compound

Usage

Building block in the synthesis of pharmaceutical drugs

Physical properties

Yellow solid, sparingly soluble in water, soluble in organic solvents such as ether and chloroform

Biological activities

Antiproliferative, antitumor, anti-inflammatory, and analgesic effects

Potential applications

Pharmaceutical and medical fields

Upstream product

• 93696-58-3 3-Bromo-4-(4-chloro-phenyl)-6-methyl-3,4-dihydro-1H-quinolin-2-one 
• 93501-35-0 β-(p-Chlorophenyl)-β-phenylacrylo-p-toluidide 
• 1615-02-7 p-chlorocinnamic acid 
• 31357-32-1 α,β-dibromo-p-chlorohydrocinnamic acid 
• 93666-26-3 α,β-dibromo-p-chlorohydrocinnamic acid chloride 
• 93501-22-5 2-Bromo-3-(4-chloro-phenyl)-3-phenyl-N-p-tolyl-propionamide 
• 93500-96-0 2,3-Dibromo-3-(4-chloro-phenyl)-N-p-tolyl-propionamide 

Relevant academic research and scientific papers

A New Route for the Synthesis of Coumarins, Thiacoumarins and Carbostyrils

3-Arylcarbostyrils, coumarins and thiacoumarins (3) have been prepared from the respective β-aryl-α-bromodihydrocinnamoyl derivatives (2) by treatment with AlCl3.The β,β-diarylacrylic acid derivatives (4) and (9), obtained from 2, on reaction with AlCl3 afford 4-arylcarbostyrils (5) 6-methyl-4-phenylthiacoumarin (10) respectively.However the oxygen analogs (11) give 3,3-diphenyl-1-indanone (12)

Synthesis of 3-Arylcoumarins, Thiacoumarins and Carbostyrils

3-Arylcarbostyrils (2a-f), coumarins (2g-j) and thiacoumarin (2k) have been prepared by a generalised method from α,β-dibromohydrocinnamoyl derivatives (1a-k).The intermediate dihydrocoumarins and dihydrocarbostyrils (3, Y = O, NH) have been prepared which on acid treatment furnish 2.However, treatment of 3 with a base affords the 4-arylcoumarins and carbostyrils (4).