93701-18-9 Usage
Uses
Used in Cholelithiasis Treatment:
2α,2β,3β,4α,4β-Pentadeuterochenodesoxycholsaeure is used as an anticholelithogenic agent for the treatment of cholesterol gallstones. It helps in dissolving gallstones by increasing the bile acid pool and reducing bile cholesterol secretion, thus preventing the formation of new stones.
Used in Liver Diseases:
2α,2β,3β,4α,4β-Pentadeuterochenodesoxycholsaeure is used as a therapeutic agent for various liver diseases, including primary biliary cirrhosis, primary sclerosing cholangitis, and cystic fibrosis-related liver disease. It exhibits choleretic, hepatoprotective, and anti-inflammatory properties, which contribute to the improvement of liver function and overall patient outcomes.
Used in Drug Delivery Systems:
2α,2β,3β,4α,4β-Pentadeuterochenodesoxycholsaeure can be used in drug delivery systems to improve the bioavailability and targeting of other therapeutic agents. Its amphiphilic nature and ability to form micelles make it a suitable carrier for hydrophobic drugs, enhancing their solubility and absorption in the body.
Used in Epimerization Studies:
As an epimer of Chenodiol with respect to the hydroxyl group at C7, 2α,2β,3β,4α,4β-Pentadeuterochenodesoxycholsaeure can be used in research to study the effects of stereochemistry on the biological activity and pharmacokinetics of bile acids and their derivatives. This knowledge can help in the development of more effective and targeted therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 93701-18-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,7,0 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 93701-18:
(7*9)+(6*3)+(5*7)+(4*0)+(3*1)+(2*1)+(1*8)=129
129 % 10 = 9
So 93701-18-9 is a valid CAS Registry Number.
93701-18-9Relevant academic research and scientific papers
Hachey,Szczepanik,Berngruber,Klein
, p. 703 - 719 (1973)
A series of 5β cholanic acids labeled with deuterium in the A ring were prepared by exchange labeling of the corresponding ketone by column chromatography on deuterated alumina. Factors affecting yield and labeling efficiency are discussed. 5β Cholanic acids labeled with 13C in the carboxyl position were prepared by treatment of the corresponding 23 chloro 24 norcholane with sodium cyanide 13C followed by alkaline hydrolysis of the nitrile. The intermediates in the synthesis were characterized by high resolution NMR spectroscopy. Mass spectra are also reported for the 13C labeled products.
