937046-97-4

Basic information

• Product Name: 1-aminopyrrole-2-carbonitrile hydrochloride
• Synonyms: 1-aminopyrrole-2-carbonitrile hydrochloride;1-amino-1H-pyrrole-2-carbonitrile hydrochloride;1-AMinopyrrole-2-carbonit...;1H-Pyrrole-2-carbonitrile, 1-amino-, hydrochloride (1:1)
• CAS NO: 937046-97-4
• Molecular Formula: C₅H₅N₃*ClH
• Molecular Weight: 143.57424
• Mol File: 937046-97-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-aminopyrrole-2-carbonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-aminopyrrole-2-carbonitrile hydrochloride(937046-97-4)
• EPA Substance Registry System: 1-aminopyrrole-2-carbonitrile hydrochloride(937046-97-4)

Safety Data

• Hazardous Substances Data: 937046-97-4(Hazardous Substances Data)

Usage

General Description

1-aminopyrrole-2-carbonitrile hydrochloride is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a hydrochloride salt of 1-aminopyrrole-2-carbonitrile, which is a building block for the synthesis of various biologically active compounds. This chemical is known for its versatile reactivity and is often used as an intermediate in the production of pharmaceuticals and agrochemicals. Its unique structure and properties make it an important component in the development of new drugs and materials with potential therapeutic and industrial applications. Additionally, the hydrochloride form of 1-aminopyrrole-2-carbonitrile helps to improve its solubility in aqueous solutions, making it easier to handle and process in laboratory settings.

Upstream product

• 937046-96-3 tert-butyl (2-cyano-1H-pyrrol-1-yl)carbamate 

Downstream Products

• 159326-68-8 pyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 937047-44-4 2-methylpyrrolo[2,1-f][1,2,4]triazin-4-amine 

Relevant articles and documents

Process for synthesizing 7 -iodopyrrolo [2,F] [1,m-triazine -4 - amine

The invention belongs to the technical field of chemical synthesis of medicines, and relates to a synthesis process of 7-iodo pyrrolo [2, 1-F] [1, 2, 4] triazine-4-amine. According to the invention, 2, 5-dimethoxy tetrahydrofuran and acethydrazide are used as initial raw materials, and are subjected to substitution, cyanation, deacetylation, cyclization and iodination reactions to obtain 7-iodopyrrolo [2, 1-F] [1, 2, 4] triazine-4-amine. The preparation method is simple, the initial raw materials are 2, 5-dimethoxytetrahydrofuran and acethydrazide which are cheap and easy to obtain. Meanwhile,the yields of the first four steps all reach 85% or above, the productivity is also greatly improved, the total yield of the product is 50% or above, and the purity can reach 99% or above. And meanwhile, the intermediate product is good in quality, so that the dosage of formamidine acetate is reduced when the intermediate IV is prepared. Through experimental comparison, the route has obvious advantages compared with the traditional process route.

PYRROLO[2,1-F] [1,2,4] TRIAZIN-4-YLAMINES IGF-1R KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER HYPERPROLIFERATIVE DISEASES

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