937273-30-8

Basic information

• Product Name: (2-(2-chloroethoxy)-5-nitrophenyl)Methanol
• Synonyms: (2-(2-chloroethoxy)-5-nitrophenyl)Methanol
• CAS NO: 937273-30-8
• Molecular Formula: C₉H₁₀ClNO₄
• Molecular Weight: 231.633
• EINECS: -0
• Mol File: 937273-30-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-(2-chloroethoxy)-5-nitrophenyl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(2-chloroethoxy)-5-nitrophenyl)Methanol(937273-30-8)
• EPA Substance Registry System: (2-(2-chloroethoxy)-5-nitrophenyl)Methanol(937273-30-8)

Safety Data

• Hazardous Substances Data: 937273-30-8(Hazardous Substances Data)

Usage

General Description

The chemical compound (2-(2-chloroethoxy)-5-nitrophenyl)Methanol, also known as clofentezine, is a synthetic acaricide and insecticide used for the control of mites and other pests in agricultural settings. It works by disrupting the molting process in mites, preventing them from reaching maturity and reproducing. Clofentezine is primarily used on a variety of food crops such as citrus fruits, strawberries, tomatoes, and ornamental plants, and is classified as a moderately hazardous chemical. Its use is regulated in many countries to minimize environmental and human health risks associated with exposure.

Upstream product

• 97-51-8 5-Nitrosalicylaldehyde 
• 110837-53-1 2-(2-chloroethoxy)-5-nitrobenzaldehyde 
• 2460-58-4 2-hydroxy-4-nitrobenzaldehyde 

Downstream Products

• 937273-31-9 1-(2-chloroethoxy)-2-((allyloxy)methyl)-4-nitrobenzene 
• 937273-32-0 1-(2-{4-nitro-2-[(prop-2-en-1-yloxy)methyl]phenoxy}ethyl)pyrrolidine 
• 1312603-46-5 4-(2-chloroethoxy)-3-((allyloxy)methyl)benzenamine 
• 937273-33-1 3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenylamine 
• 1312603-57-8 N-(4-(2-chloroethoxy)-3-((allyloxy)methyl)phenyl)-4-(3-((allyloxy)methyl)phenyl)pyrimidin-2-amine 
• 1312603-61-4 [4-(3-allyloxymethylphenyl)-5-methylpyrimidin-2-yl]-[ 3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1312603-62-5 [4-(3-allyloxymethylphenyl)-5-fluoropyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1312603-63-6 [4-(5-allyloxymethyl-2-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1312603-64-7 [4-(3-allyloxymethyl-5-fluorophenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1312603-65-8 [4-(3-allyloxymethyl-4-methoxyphenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1312603-66-9 [4-(3-allyloxymethyl-4-fluorophenyl)-pyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-yl-ethoxy)phenyl]amine 
• 1364124-02-6 [4-(1-allyl-1H-indol-6-yl)-5-methylpyrimidin-2-yl]-[3-allyloxymethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]amine 
• 1083182-45-9 [3-allyloxymethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]-[4-(2-fluoropyridin-4-yl)-5-methylpyrimidin-2-yl]amine 
• 1083182-44-8 [3-allyloxymethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]-[4-(2-fluoropyridin-4-yl)pyrimidin-2-yl]amine 

Relevant articles and documents

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

Blockage of more than one oncoprotein or pathway is now a standard approach in modern cancer therapy. Multiple inhibition is typically achieved with two or more drugs. Herein, we describe a pharmacophore merging strategy combining the JAK2/FLT3 inhibitor pacritnib with the pan-HDAC inhibitor, vorinostat, to create bispecific single molecules with both JAK and HDAC targeted inhibition. A preferred ether hydroxamate, 51, inhibits JAK2 and HDAC6 with low nanomolar potency, is 50-fold selective for JAK2 in a panel of 97 kinases. Broad cellular antiproliferative potency is supported by demonstration of JAK-STAT and HDAC pathway blockade in several hematological cell lines, inhibition of colony formation in HEL cells, and analysis of apoptosis. This study provides new tool compounds for further exploration of dual JAK-HDAC pathway inhibiton achieved with a single molecule.

INDOLE SUSTITUTED PYRIMIDINES AND USE THEREOF IN THE TREATMENT OF CANCER

The present invention relates to pyrimidine compounds of formula (I) that are useful as anti proliferative agents. More particularly, the present invention relates to indole substituted pyrimidine compounds, methods for their preparation, pharmaceutical c

PYRIDYL SUBSTITUTED PYRIMIDINE DERIVATIVES

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