937372-03-7Relevant articles and documents
Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives
Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav
supporting information, (2018/12/11)
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii
Evans, Kathryn M.,Haraldsen, Jeralyn D.,Pearson, Russell J.,Slawin, Alexandra M. Z.,Ward, Gary E.,Westwood, Nicholas J.
, p. 2063 - 2069 (2008/03/18)
The use of phenotype-based screens as an approach for identifying novel small molecule tools is reliant on successful protein target identification strategies. Here we report on the synthesis and chemical characterisation of a novel reagent for protein ta
