937377-68-9Relevant articles and documents
NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding site
Bretonnet, Anne-Sophie,Jochum, Anne,Walker, Olivier,Krimm, Isabelle,Goekjian, Peter,Marcillat, Olivier,Lancelin, Jean-Marc
, p. 1865 - 1875 (2007)
Using an in-house fragment NMR library, we identified a set of ligands that bind rabbit muscular creatine kinase, an enzyme involved in key ATP-dependent processes. The ligands docked to the crystal structures of creatine kinase indicated that a phenylfur
