93745-57-4Relevant articles and documents
Convenient Synthesis of Fused Heterocycles from α-Ketohydroximoyl Chlorides and Heterocyclic Amines
Parkanyi, Cyril,Abdelhamid, Abdou O.,Cheng, John C. S.
, p. 1029 - 1032 (2007/10/02)
Nitroso derivatives of imidazopyridine (11,13,14), imidazopyrimidine (15), imidazopyrazine (16), imidazopyrazole (17), and imidazo-1,2,4-triazole (19) were obtained in good yields from α-ketohydroximoyl chlorides 3 and 2-aminopyrazines (4-6), 2-aminopyrimidine (7), 2-aminopyrazine (8), 5-amino-3-phenylpyrazole (9), and 3-amino-2H-1,2,4-triazole (10), respectively.Under different conditions, the reaction of 3 with 3-amino-2H-1,2,4-triazole (10) and 2-aminopyrazine (8) afforded the noncyclized substitution products 18 and 22, respectively.The structures of the products were assigned and confirmed on the basis of their elemental analyses, spectral data, and alternate synthesis wherever possible.