93747-67-2

Upstream product

• 6968-35-0 7-hydroxy-indan-1-one 
• 106-95-6 allyl bromide 

Relevant academic research and scientific papers

Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives

To developed a novel cerebroprotective agent with central nervous system (CNS) stimulating activity, a series of 1-amino-7-hydroxyindan derivatives was synthesized, and their effects on the survival time of mice under hypoxic conditions were tested.CNS-stimulating activity was also evaluated by examining the promotional effect on the recovery from cerebral concussion induced coma in mice.Several compounds prolonged the survival time of mice in hypoxic conditions at a dose of 30 mg/kg (sc or ip) and 100 mg/kg (po).They also exhibited the promotional effects on recovery from coma at a dose of 100 mg/kg po.The three most potent compounds in both tests, 1-amino-7-hydroxy-6-(1-methylpropyl)indan (20), 1-amino-7-hydroxy-4,6-dimethyl-2-phenylindan (30), and 1-amino-7-hydroxy,2,2,4,6-tetramethylindan (35) were selected for further investigations.Structure-activity relationships were also discussed.

SYNTHESIS OF TETRAHYDRODICRANENONE B

The naturally occuring cyclopentenone, tetrahydrodicranenone B (1), has been synthesized from the cyclopentenone (3), prepared by Birch reduction/alkylation of 6-methoxyindanone followed by ozonolysis of the dihydroindanone (2).The lower side chain was elongated by selective addition of a five-carbon Grignard reagent to the aldehyde (6), obtained from the ester (3), to give the alcohol (7).The alcohol (7) could also be prepared from the 7-methoxyindanone (14), in which all the carbons of the lower side chain are already present, by a similar reductive alkylation/ozonolysis sequence (Scheme 3).The alcohol (7) was converted into the natural product by radical deoxygenation, followed by functional group manipulation.