93748-07-3

Usage

Uses

Used in Organic Synthesis:
α,α,3,5-TetraMethyl-benzeneacetonitrile is used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. The presence of the nitrile group and methyl groups on the benzene ring makes it a valuable precursor for the formation of amines, amides, and other nitrogen-containing compounds through various chemical reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, α,α,3,5-TetraMethyl-benzeneacetonitrile is used as a key intermediate in the synthesis of certain drugs. Its ability to be converted into various functional groups makes it a valuable component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
α,α,3,5-TetraMethyl-benzeneacetonitrile also finds application in the agrochemical industry, where it serves as a starting material for the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity contribute to the development of effective and targeted agrochemical products.

Upstream product

• 60-29-7 diethyl ether 
• 39101-54-7 3,5-dimethylphenylacetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 854634-86-9 2-(3,5-dimethyl-phenyl)-2-methyl-propionic acid amide 
• 120512-36-9 2-(3-bromomethyl-5-methylphenyl)-2-methylpropionitrile 
• 857543-93-2 5-(1-carboxy-1-methyl-ethyl)-isophthalic acid 
• 93748-16-4 2-(3,5-dimethyl-phenyl)-2-methyl-propionic acid 

Relevant academic research and scientific papers

Preparation method of anastrozole derivatives

The invention discloses a preparation method of anastrozole derivatives, and belongs to the field of drug synthesis. The method has the advantages of reasonable process design, strong operability, mild reaction conditions and high yield and can realize in

Dual aromatase-sulfatase inhibitors based on the anastrozole template: Synthesis, in vitro SAR, molecular modelling and in vivo activity

The synthesis and biological evaluation of a series of novel Dual Aromatase-Sulfatase Inhibitors (DASIs) are described. It is postulated that dual inhibition of the aromatase and steroid sulfatase enzymes, both responsible for the biosynthesis of oestrogens, will be beneficial in the treatment of hormone-dependent breast cancer. The compounds are based upon the Anastrozole aromatase inhibitor template which, while maintaining the haem ligating triazole moiety crucial for enzyme inhibition, was modified to include a phenol sulfamate ester motif, the pharmacophore for potent irreversible steroid sulfatase inhibition. Adaption of a synthetic route to Anastrozole was accomplished via selective radical bromination and substitution reactions to furnish a series of inhibitory aromatase pharmacophores. Linking these fragments to the phenol sulfamate ester moiety employed SN2, Heck and Mitsunobu reactions with phenolic precursors, from where the completed DASIs were achieved via sulfamoylation. In vitro, the lead compound, 11, had a high degree of potency against aromatase (IC50 3.5 nM), comparable with that of Anastrozole (IC50 1.5 nM) whereas, only moderate activity against steroid sulfatase was found. However, in vivo, 11 surprisingly exhibited potent dual inhibition. Compound 11 was modelled into the active site of a homology model of human aromatase and the X-ray crystal structure of steroid sulfatase. This journal is The Royal Society of Chemistry.