93748-24-4Relevant academic research and scientific papers
Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
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Paragraph 2271, (2019/03/30)
The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
VARYING RESONANCE DEMANDS IN SUBSTITUENT EFFECTS. ACETOLYSIS OF NEOPHYL p-BROMOBENZENESULFONATES
Fujio, Mizue,Funatsu, Kimito,Goto, Mutsuo,Mishima, Masaaki,Tsuno, Yuho
, p. 307 - 316 (2007/10/02)
Rates of acetolysis of 2-aryl-2-methylpropyl p-bromobenzenesulfonates were determined for an extended series of substituents.The substituent effect can be described accurately in terms of our LArSR relationship (Yukawa-Tsuno Equation), giving an r value of 0.57.The correlation result can be reasonably accounted for on the basis of the accepted mechanism of this reaction, involving a rate-determining aryl-assisted transition state.The present study leads to the conclusion that this unique r value should be related to the resonance demand characteristic of the aryl-assisted ionization process of this reaction.The simple application of the Brown ρ?+ equation or its extended treatment and the interpretation based thereon are criticized.
