93752-75-1

Upstream product

• 2179-79-5 phenyl selenocyanate 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 693783-96-9 benzyl 4-hydroxy-5-phenylselanylpentanoate 
• 693783-93-6 propyl 4-hydroxy-5-phenylselanylpentanoate 
• 693783-95-8 methyl 4-hydroxy-5-(phenylseleno)pentanoate 

Downstream Products

• 92998-78-2 (R)-(+)-α-(2-chlorobenzylidene)-γ-methyl-γ-butyrolactone 
• 58917-25-2 (R)-5-methyl-2-oxotetrahydrofuran 

Relevant academic research and scientific papers

Enzymatic Resolution of 5-Phenylselanyltetrahydro-2-furanone. Enantioselective Preparation of (R) and (S)-γ-Valerolactone

Lipase-catalyzed lactonization of (2) provides both (R) and (S) enantiomers of 5-phenylselenyltetrahydro-2-furanone (1) in good enantiomeric excess. The kinetic resolution was examined using PPL (Porcine pancreatic lipase), PSL (Amano PS, Pseudomonas sp. lipase), MML (Mucor miehei lipase), CRL (Candida rugosa lipase), CAL-B (Candida Antarctica lipase, type B) and Novozym 435 (immobilized C. antarctica lipase type B) in different solvents. A tributyltin hydride reduction of enantiomerically enriched 1 gave both (R) and (S) enantiomers of S-4-pentanolide (γ-valerolactone).

A Novel Class of Fungicides: Synthesis of (R)- and (S)-&α-Benzylidene-&γ-methyl-&γ-butyrolactones

The enantiomers of α-benzylidene-γ-methyl-γ-butyrolactones, a novel class of fungicides, were prepared stereospecifically from (R)- and (S)-γ-methyl-γ-butyrolactones.The results of their fungicidal evaluation are also described.