93752-75-1

Basic information

• Product Name: 2(3H)-Furanone, dihydro-5-[(phenylseleno)methyl]-, (S)-
• CAS NO: 93752-75-1
• Molecular Formula: C11H12O2Se
• Molecular Weight: 255.175
• Mol File: 93752-75-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-5-[(phenylseleno)methyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-5-[(phenylseleno)methyl]-, (S)-(93752-75-1)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-5-[(phenylseleno)methyl]-, (S)-(93752-75-1)

Safety Data

• Hazardous Substances Data: 93752-75-1(Hazardous Substances Data)

Upstream product

• 693783-96-9 benzyl 4-hydroxy-5-phenylselanylpentanoate 
• 693783-93-6 propyl 4-hydroxy-5-phenylselanylpentanoate 
• 693783-95-8 methyl 4-hydroxy-5-(phenylseleno)pentanoate 
• 2179-79-5 phenyl selenocyanate 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 92998-78-2 (R)-(+)-α-(2-chlorobenzylidene)-γ-methyl-γ-butyrolactone 
• 58917-25-2 (R)-5-methyl-2-oxotetrahydrofuran 

Relevant articles and documents

Enzymatic Resolution of 5-Phenylselanyltetrahydro-2-furanone. Enantioselective Preparation of (R) and (S)-γ-Valerolactone

Lipase-catalyzed lactonization of (2) provides both (R) and (S) enantiomers of 5-phenylselenyltetrahydro-2-furanone (1) in good enantiomeric excess. The kinetic resolution was examined using PPL (Porcine pancreatic lipase), PSL (Amano PS, Pseudomonas sp. lipase), MML (Mucor miehei lipase), CRL (Candida rugosa lipase), CAL-B (Candida Antarctica lipase, type B) and Novozym 435 (immobilized C. antarctica lipase type B) in different solvents. A tributyltin hydride reduction of enantiomerically enriched 1 gave both (R) and (S) enantiomers of S-4-pentanolide (γ-valerolactone).