93764-53-5Relevant academic research and scientific papers
C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**
Ghosh, Prithwish,Kwon, Na Yeon,Kim, Saegun,Han, Sangil,Lee, Suk Hun,An, Won,Mishra, Neeraj Kumar,Han, Soo Bong,Kim, In Su
, p. 191 - 196 (2020/10/29)
The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.
INTRODUCTION OF THE METHYL GROUP INTO THE PYRAZINE RING
Ohta, Akihiro,Inoue, Akira,Watanabe, Tokuhiro
, p. 2317 - 2321 (2007/10/02)
By the coupling reaction of mono- and dichloropyrazines with trimethylaluminum in the presence of a palladium catalyst, the corresponding mono- and dimethylpyrazines were prepared in excellent yields.
