93765-34-5

Basic information

• Product Name: 5-Pyrimidinemethanol, a-(4-chlorophenyl)-a-(4-fluorophenyl)-
• CAS NO: 93765-34-5
• Molecular Formula: C17H12ClFN2O
• Molecular Weight: 314.746
• Mol File: 93765-34-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinemethanol, a-(4-chlorophenyl)-a-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinemethanol, a-(4-chlorophenyl)-a-(4-fluorophenyl)-(93765-34-5)
• EPA Substance Registry System: 5-Pyrimidinemethanol, a-(4-chlorophenyl)-a-(4-fluorophenyl)-(93765-34-5)

Safety Data

• Hazardous Substances Data: 93765-34-5(Hazardous Substances Data)

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 2069-48-9 4-chloro-4'-fluoro-benzophenone 

Downstream Products

• 93765-54-9 5-[(4-Chloro-phenyl)-fluoro-(4-fluoro-phenyl)-methyl]-pyrimidine 

Relevant articles and documents

Aromatase Inhibition by 5-Substituted Pyrimidines and Dihydropirimidines

The inhibition of estrogen biosynthesis has been suggested to be an effective treatment of hormone-dependent diseases, particularly breast cancer.Several series of 5-substituted pyrimidine derivatives have been synthesized and tested for their ability to inhibit the enzyme aromatase (estrogen synthetase).Compounds were evaluated in an in vitro assay that measured the inhibition of rat ovarian microsomal aromatase activity.Greatest inhibitory activity was achieved in the cases of diarylpyrimidinemethanols and diarylpyrimidinyl methanes which were substituted in the 4- and 4'-positions with electron-withdrawing substituents, particularly Cl.