937665-05-9Relevant academic research and scientific papers
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
Huhtiniemi, Tero,Suuronen, Tiina,Rinne, Valtteri M.,Wittekindt, Carsten,Lahtela-Kakkonen, Maija,Jarho, Elina,Wallén, Erik A. A.,Salminen, Antero,Poso, Antti,Lepp?nen, Jukka
supporting information; experimental part, p. 4377 - 4380 (2009/06/17)
A new inhibitor for human sirtuin type proteins 1 and 2 (SIRT1 and SIRT2) was discovered through virtual database screening in search of new scaffolds. A series of compounds was synthesized based on the hit compound (3-[[3-(4-tert-butylphenyl)1,2,4-oxadiazole-5-carbonyl]ammo]-1-[3- (trifluoromethyl)phenyl]thiourea). The most potent compound in the series was nearly as potent as the reference compound (6-chloro-2,3,4,9-tetrahydro-1H- carbazole-1-carboxamide).
