937681-12-4

Basic information

• Product Name: 2,2-DiMethylpiperidin-4-ol
• Synonyms: 2,2-DiMethylpiperidin-4-ol;2,2-Dimethyl-4-piperidinol;4-Piperidinol, 2,2-dimethyl-
• CAS NO: 937681-12-4
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Mol File: 937681-12-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 78℃ (ethanol water )
• Boiling Point: 66℃ (0.2 Torr)
• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,2-DiMethylpiperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DiMethylpiperidin-4-ol(937681-12-4)
• EPA Substance Registry System: 2,2-DiMethylpiperidin-4-ol(937681-12-4)

Safety Data

• Hazardous Substances Data: 937681-12-4(Hazardous Substances Data)

Usage

Uses

2,2-Dimethyl-4-piperidinol is an intermediate used to prepare diphenylpyraline derivatives with antimycobacterial activities.

Upstream product

• 77747-72-9 5,6-Dihydro-4-hydroxy-6,6-dimethyl-2(1H)-pyridinthion 

Relevant articles and documents

Antimycobacterial activity of diphenylpyraline derivatives

2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity against Mycobacterium tuberculosis H37Rv as well as their cytotoxicity against human cells (HEK-293) have been determined via in vitro assays. The antimycobacterial potency was in general increased by substitution in ring position 2. The most promising modifications were a 2-isopropyl derivative and a 1,2-diphenyl analogue.