937738-35-7Relevant academic research and scientific papers
Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)
Pitsinos, Emmanuel,Athinaios, Nikolaos,Xu, Zhaoqing,Wang, Guangwei,Negishi, Ei-Ichi
supporting information; experimental part, p. 2200 - 2202 (2010/07/09)
(+)-Scyphostatin (1) was synthesized via (i) construction of a side-chain 3b of ≥98% purity in 19% yield in eleven steps featuring ZACA reaction, Negishi coupling, and HWE olefination, (ii) an asymmetric synthesis of a fully protected core 4 from 10a, and (iii) a three-step assembly of 1 in 42% yield.
