937795-17-0

Basic information

• Product Name: C₁₆H₁₄O₂CH₄
• Synonyms: C₁₆H₁₄O₂CH₄
• CAS NO: 937795-17-0
• Molecular Weight: 254.329
• Mol File: 937795-17-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₄O₂CH₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₄O₂CH₄(937795-17-0)
• EPA Substance Registry System: C₁₆H₁₄O₂CH₄(937795-17-0)

Safety Data

• Hazardous Substances Data: 937795-17-0(Hazardous Substances Data)

Upstream product

• 937795-06-7 BrC₆H₄C₃H₅O₂CH₂ 
• 16419-60-6 2-Methylphenylboronic acid 
• 106948-05-4 [(2S,3S)-3-(4-bromophenyl)oxiran-2-yl]methanol 

Relevant articles and documents

Suzuki cross-coupling on enantiomerically pure epoxides: Efficient synthesis of diverse, modular amino alcohols from single enantiopure precursors

(Chemical Equation Presented) Suzuki arylation of enantiopure (4-bromophenyl)- or (3,5-dibromophenyl)glycidyl ethers has been achieved in toluene under Buchwald conditions [ArB(OH)2 (1.1 equiv), Cs 2CO3 (2 equiv), Pd2(dba)3· C6H6 (1 mol %), S-Phos (4 mol %), toluene, 100°C] allowing for the formation of modular arylglycidyl ethers not directly available in enantiopure form by epoxidation routes. These bulky ethers, when submitted to regioselective and stereospecific ring opening with ammonia [aq NH 3, LiClO4 (1 equiv), THF, microwave irradiation (80 W), 125°C] in a sealed tube, provide access to novel enantiopure β-amino alcohols which, in turn, provide an easy access to structurally complex C 2 symmetrical bisoxazolines.