937806-10-5Relevant articles and documents
Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W.,Vickers, Troy D.,Tamiya, Junko,Zhang, Mingzhu,Dyck, Brian,Grey, Jonathan,Schwarz, David,Heise, Christopher E.,Hedrick, Michael,Wen, Jenny,Tang, Hui,Wang, Hua,Fisher, Andrew,Aparicio, Anna,Saunders, John,Goodfellow, Val S.
, p. 2171 - 2178 (2007/10/03)
The design, synthesis, and SAR of a series of substituted spirohydantoins are described. Optimization of an in-house screening hit gave compounds that exhibited potent binding affinity and functional activity at MCH-R1.