93798-49-3Relevant academic research and scientific papers
Substituted thiadiazole, oxadiazole, triazole and triazinone as antimicrobial and surface activity compounds
El-Sayed
, p. 39 - 47 (2013/03/13)
Stearic acid (1) was utilized as a new cheap starting material in the manufacture of important biologically active heterocycles as thiadiazole, oxadiazole, triazole and triazinone derivatives (2-11) by treating with different nucleophiles. These heterocycles bears active hydrogen atom (SH, NH and NH2) which could be propoxylated by different moles of propylene oxide (5, 10, 15 mol) to produce nonionic compounds (12-21)a-c having functions as surface and antimicrobial activities. The structural elucidation of these compounds is based on IR, 1H NMR, 13C NMR and elemental analysis. The surface properties (surface and interfacial tension, cloud point, witting time, foaming properties and emulsion stability) and the biodegradability were screened beside these compounds have been tested for their antimicrobial activity. Graphical Abstract: Stearic acid 1 was utilized as a new cheap starting material in the manufacture of important biologically active heterocycles as thiadiazole, oxadiazole, triazole and triazinone derivatives by treating with different nucleophile at different reaction conditions.[Figure not available: see fulltext.]
Synthesis of 1-Nonanoyl/octadecanoyl-4-substituted Thiosemicarbazides and substituted 1,2,4-Trizoles as biological active compounds
Colanceska-Ragenovic, Katica,Dimova, Vesna,Kakurinov, Vlado,Gabor, Dora Molnar
, p. 905 - 908 (2007/10/03)
4-Alkyl/aryl-5-nonanoyl/octadecanoyl-2,4-dihydro-3H-1,2, 4-triazoline-3-thiones were synthesized as potential antimicrobial agents. The course of synthesis included the reaction of nonanoyl/octadecanoyl hydrazines with selected alkyl/aryl isothiocyanates. The prepared thiosemicarbazides gave by cyclization the required 1,2,4-triazoles. A number of synthesized compounds were subjected to in vitro testing against two gram-positive, two gram-negative bacteria and two fungi.
