938055-35-7Relevant academic research and scientific papers
On the origins of diastereoselectivity in the alkylation of diketopiperazine enolates
Bull, Steven D.,Davies, Stephen G.,Garner, A. Christopher,Parkes, Alastair L.,Roberts, Paul M.,Sellers, Thomas G. R.,Smith, Andrew D.,Tamayo, Juan A.,Thomson, James E.,Vickers, Richard J.
, p. 486 - 495 (2007)
High levels of diastereoselectivity are observed for benzylation of the lithium enolates of (S)-N,N′-bis-para-methoxybenzyl-3-iso-propyl- piperazine-2,5-dione, (S)-N(1)-para-methoxybenzyl-N(4)-methyl-3-iso-propyl- piperazine-2,5-dione and (S)-N(1)-methyl-
Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates
Davies, Stephen G.,Christopher Garner,Ouzman, Jaqueline V. A.,Roberts, Paul M.,Smith, Andrew D.,Snow, Emma J.,Thomson, James E.,Tamayo, Juan A.,Vickers, Richard J.
, p. 2138 - 2147 (2008/03/14)
Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.
