938064-72-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(hydroxymethyl)Cyclobutanecarbonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be chemically transformed into a range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(hydroxymethyl)Cyclobutanecarbonitrile is utilized as an intermediate in the production of different agrochemicals, contributing to the development of substances that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
3-(hydroxymethyl)Cyclobutanecarbonitrile is used as a key building block in organic synthesis for its capacity to participate in various chemical reactions, enabling the creation of a wide array of organic compounds.

Upstream product

• 15760-35-7 3-methylenecyclobutanecarbonitrile 

Downstream Products

• 938064-73-4 3-(4-methoxy-benzyloxymethyl)-cyclobutanecarbonitrile 
• 89941-55-9 methyl 3-(hydroxymethyl)cyclobutane-1-carboxylate 
• 1370705-51-3 (R)-2-{N-{[(1s,3s)-3-(1,2,4-Oxadiazol-3-yl)cyclobutyl]methyl}-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide 
• 1370705-46-6 (R)-2-{4-chloro-N-{[(1r,3r)-3-cyanocyclobutyl]methyl}phenylsulfonamido}-5,5,5-trifluoropentanamide 
• 1370705-45-5 (R)-2-{4-chloro-N-{[(1s,3s)-3-cyanocyclobutyl]methyl}-phenylsulfonamido}-5,5,5-trifluoropentanamide 

Relevant academic research and scientific papers

Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks

Drug discovery building blocks available commercially or within an internal inventory cover a diverse range of chemical space and yet describe only a tiny fraction of all chemically feasible reagents. Vendors will eagerly provide tools to search the former; there is no straightforward method of mining the latter. We describe a procedure and use case in assembling chemical structures not available for purchase but that could likely be synthesized in one robust chemical transformation starting from readily available building blocks. Accessing this vast virtual chemical space dramatically increases our curated collection of reagents available for medicinal chemistry exploration and novel hit generation, almost tripling the number of those with 10 or fewer atoms.

Substituted imidazole formate type derivative and application thereof

The invention discloses a compound shown as a formula I or a stereoisomer thereof or pharmaceutically acceptable salts thereof or a solvate thereof or a prodrug thereof or a metabolic product thereofor a deuterated derivative thereof. The compound is a substituted imidazole formate type derivative with a novel structure and belongs to the field of pharmaceutical chemistry. The invention further discloses application of the substituted imidazole formate type derivative to preparation of drugs with calming, hypnosis and/or anesthetic effects and application of the substituted imidazole formatetype derivative to preparation of drugs capable of controlling status epilepticus. The compound disclosed by the invention has a relatively good inhibition effect on a central nervous system and provides a new choice for clinically screening and/or preparing the drugs with the calming, hypnosis and/or anesthetic effects and capable of controlling the status epilepticus. The formula I is shown in the description.

AZETIDINE DERIVATIVES AS GLYT1 INHIBITORS

The present invention relates to compounds of formula (I); and pharmaceutically acceptable salts thereof and individual enantiomers and diastereomers thereof, as GIyTl inhibitors for treating neurological and psychiatric disorders.