938065-78-2Relevant academic research and scientific papers
A carbocyclic 7-deazapurine-pyrimidine hybrid nucleoside
Sunkara, Naresh K.,Mosley, Sylvester L.,Seley-Radtke, Katherine L.
, p. 1161 - 1168 (2006)
The design, synthesis and rationale for the first example of a carbocyclic 7-deazapurine-pyrimidine hybrid nucleoside is described. The marriage of key structural features from the purine and pyrimidine nucleobase scaffolds has given rise to novel hybrid
"Reverse" carbocyclic fleximers: Synthesis of a new class of adenosine deaminase inhibitors
Zimmermann, Sarah C.,Sadler, Joshua M.,O'Daniel, Peter I.,Kim, Nathaniel T.,Seley-Radtke, Katherine L.
, p. 137 - 154 (2013/05/21)
A series of flexible carbocyclic pyrimidine nucleosides has been designed and synthesized. In contrast to previously reported "fleximers" from our laboratory, these analogues have the connectivity of the heterocyclic base system "reversed", where the pyri
Carbocyclic pyrimidine nucleosides as inhibitors of S-adenosylhomocysteine hydrolase
Mosley, Sylvester L.,Bakke, Brian A.,Sadler, Joshua M.,Sunkara, Naresh K.,Dorgan, Kathleen M.,Zhou, Zhaohui Sunny,Seley-Radtke, Katherine L.
, p. 7967 - 7971 (2007/10/03)
The design, synthesis, and unexpected inhibitory activity against S-adenosyl-homocysteine (SAH) hydrolase (SAHase, EC 3.3.1.1) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was fou
