938066-17-2Relevant academic research and scientific papers
PROCESS FOR THE MANUFACTURE OF 1,4-DISUBSTITUTED PYRIDAZINE COMPOUNDS
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Page/Page column 62-63, (2022/01/05)
The invention relates to a novel process, novel process step(s) and novel intermediate(s) useful for the preparation of 1,4-disubstituted pyridazine compounds, such as 5-(1 H-Pyrazol-4-yl)-2-(6- ((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol.
20-HETE FORMATION INHIBITORS
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Paragraph 0221-0224, (2020/08/23)
This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.
Preparation method of nitrogen unsubstituted-4-formyl pyrazole
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Paragraph 0050; 0052-0054, (2020/02/14)
The invention relates to a preparation method of nitrogen unsubstituted-4-formyl pyrazole. The preparation method comprises the following steps: taking 4-halogenated pyrazole or a 4-halogenated pyrazole derivative as a raw material; under the action of trifluoroacetic acid, carrying out reaction with 3, 4-dihydro-2H-pyrane to generate 4-halogenated-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; carrying out lithiation reaction of 4-halogenated-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole and n-butyllithium at a low temperature, adding N, N-dialkyl formamide and other formylation reagents to introduceformyl, hydrolyzing in an acidic aqueous solution to remove protecting groups, and purifying to obtain the nitrogen unsubstituted-4-formyl pyrazole. The nitrogen unsubstituted-4-formyl pyrazole prepared by the preparation method disclosed by the invention is good in biological activity and has wide application in the fields of medicines and pesticides.
NAPHTHYRIDINES AS INHIBITORS OF HPK1
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Paragraph 1171; 1172, (2018/10/21)
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
1,1′-Bis(pyrazol-4-yl)ferrocenes: Potential Clip Ligands and Their Supramolecular Structures
Veronelli, Mattia,Dechert, Sebastian,Schober, Anne,Demeshko, Serhiy,Meyer, Franc
, p. 446 - 453 (2017/02/05)
Two ferrocene derivatives with pyrazoles appended at their C-4 position to both cyclopentadienyl (Cp) rings have been synthesized, namely, 1,1′-bis(1H-pyrazol-4-yl)ferrocene (H2HL) and 1,1′-bis(3,5-dimethyl-1H-pyrazol-4-yl)ferrocene (H2MeL). In the solid state, these are shown crystallographically to form supramolecular aggregates through intermolecular NH···N hydrogen bonds in either a dimeric (H2HL) or trimeric (H2MeL) arrangement. Variable-temperature NMR spectroscopy and diffusion-ordered spectroscopy (DOSY) evidenced the presence of [H2MeL]3trimers in [D8]toluene solution, whereas both H2HL and H2MeL exist as monomers in deuterated N,N-dimethylformamide ([D7]DMF) even at low temperatures. The kinetic parameters for the NH tautomerism have been determined. In their dianionic forms, both of these hybrid ferrocene/pyrazole molecules serve as ligands towards CuI, AgI, and AuIions. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) revealed the formation of [M2RL]3hexametallic complexes, the structures of which are suggested to have D3hsymmetry with two metallomacrocyclic [M(μ-pz)]3(pz = pyrazolate) decks connected by three ferrocene clips. M?ssbauer spectra and preliminary luminescence data were collected for the proligands and the resulting complexes. Owing to the insolubility of the coinage-metal complexes, the electrochemical properties could be measured only for the two H2RL proligands.
Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors
Liu, Tao,Zhan, Wenhu,Wang, Yanming,Zhang, Liangren,Yang, Bo,Dong, Xiaowu,Hu, Yongzhou
, p. 167 - 176 (2014/01/17)
A series of diphenylmethylamine derivatives were rationally designed, synthesized and biologically evaluated. Most of them exhibited moderate to good Akt1 inhibitory activities, as well as promising anti-proliferative efficacy against cancer cell lines. Besides, molecular docking studies were carried out to probe their binding modes with Akt1. Further kinase selectivity studies of compound 22c were performed, indicating its excellent selectivity against Aurora A, Drak, IKKβ, GSK3β, SYK and JAK2, and moderate selectivity against PKC and BRAF. Finally, a refined pharmacophore model was generated using the most active compounds 2, 12c and 22c via application of HipHop program.
Functionalized pyrazoles as agents in C-C cross-coupling reactions
Pejic, Marijana,Popp, Sebastian,Bolte, Michael,Wagner, Matthias,Lerner, Hans-Wolfram
, p. 83 - 97 (2014/06/09)
The 1-tetrahydropyranyl-(THP-)protected pyrazoles 4-R-pz(THP) (R=pinacolatoboryl=Bpin (3a(THP)), Me3Si (4a(THP)), Me3Sn (5a(THP)), and 4-R-3,5-Ph2pz (R=Bpin (3b(THP)), Me3Si (4b(THP)), Me3Sn (5b(THP))
Indium-mediated synthesis of heterobiaryls
Font-Sanchis, Enrique,Cespedes-Guirao, F. Javier,Sastre-Santos, Angela,Fernandez-Lazaro, Fernando
, p. 3589 - 3591 (2008/02/04)
The palladium-mediated coupling reaction between triorganoindium reagents and organic electrophiles is extended to the synthesis of heteroaromatic compounds. Both electron-rich and electron-poor heterocycles can act as the organic electrophile or as the organoindium derivative.
