938075-17-3

Basic information

• Product Name: C₁₆H₁₅ClF₃N₃O
• CAS NO: 938075-17-3
• Molecular Weight: 357.763
• Mol File: 938075-17-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₅ClF₃N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₅ClF₃N₃O(938075-17-3)
• EPA Substance Registry System: C₁₆H₁₅ClF₃N₃O(938075-17-3)

Safety Data

• Hazardous Substances Data: 938075-17-3(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 879131-25-6 6-chloro-5-tert-butylpyrazine-2-carboxylic acid chloride 

Relevant articles and documents

Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via -CONH- bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of 20 newly synthesized compounds are presented. Structure-activity relationships among the chemical structures, the antimycobacterial, antifungal, photosynthesis inhibiting and antialgal activity of the evaluated substituted N-phenylpyrazine-2-carboxamides are discussed. 5-tert-Butyl-6-chloro-N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (19) has shown the highest activity against Mycobacterium tuberculosis H37Rv (MIC = 3.13 μg/mL). The highest antifungal effect against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (14, MIC = 62.5 μmol/mL). The highest reduction of chlorophyll content in Chlorella vulgaris was found for pyrazine-2-carboxylic acid (3-trifluoromethylphenyl)amide (9, IC50 = 12.1 μmol/L).