938230-55-8

Basic information

• Product Name: 4-(4-chlorophenoxy)benzene-1-carbothioamide
• Synonyms: 4-(4-chlorophenoxy)benzene-1-carbothioamide
• CAS NO: 938230-55-8
• Molecular Formula: C₁₃H₁₀ClNOS
• Molecular Weight: 263.74
• Mol File: 938230-55-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-chlorophenoxy)benzene-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenoxy)benzene-1-carbothioamide(938230-55-8)
• EPA Substance Registry System: 4-(4-chlorophenoxy)benzene-1-carbothioamide(938230-55-8)

Safety Data

• Hazardous Substances Data: 938230-55-8(Hazardous Substances Data)

Upstream product

• 106-48-9 4-chloro-phenol 
• 1194-02-1 4-fluorobenzonitrile 
• 74448-92-3 4-(4'-chlorophenoxy)benzonitrile 

Downstream Products

• 1333152-98-9 C₁₄H₁₀ClN₃O 
• 1415596-10-9 C₂₅H₂₂ClNO₂S 
• 1415596-26-7 C₃₂H₃₇ClN₂O₂S 
• 1415596-24-5 C₃₃H₃₇ClN₂O₂S 
• 1415596-02-9 C₂₅H₂₂ClNO₂S 
• 1415596-18-7 C₃₂H₃₇ClN₂O₂S 
• 1415596-16-5 C₃₃H₃₇ClN₂O₂S 
• 1415596-08-5 C₃₂H₂₈ClNO₂S 
• 1415596-00-7 C₃₂H₂₈ClNO₂S 
• 1333152-97-8 C₁₄H₁₂ClNOS 

Relevant articles and documents

Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease

A series of thiazole derivatives were designed, and prepared to develop RAGE antagonist for the treatment of Alzheimer's disease (AD). SAR studies were performed to optimize inhibitory activity on Aβ-RAGE binding. SAR studies showed that introducing an amino group at part A was essential for inhibitory activity on Aβ-RAGE binding. Compounds selected from Aβ-RAGE binding screening displayed inhibitory activity on Aβ transport across BBB. They also showed inhibitory activity against Aβ-induced NF-κB activation. These results indicated that our derivatives had a potential as therapeutic agent for the treatment of AD.