938307-34-7

Usage

Class

Piperazine derivative

Structure

Piperazine ring with propylamine group and 2,3-dimethylphenyl group attached

Uses

Building block in synthesis of pharmaceuticals and agrochemicals
Potential applications in medicinal chemistry for developing CNS-targeting drugs
Reagent in chemical research
Intermediate in production of other organic compounds

Upstream product

• 1013-22-5 1-(2,3-dimethylphenyl)piperazine 
• 1220831-49-1 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione 

Downstream Products

• 1044529-58-9 C₂₂H₂₇N₇O₂ 
• 1044529-21-6 C₂₂H₂₇N₇O₂ 
• 1044529-66-9 C₂₃H₂₈N₆O₂ 
• 1044529-25-0 Z₀₆₆-0150 
• 1240266-82-3 C₂₈H₃₈N₄O*ClH 
• 1292802-40-4 C₂₈H₃₄N₆O 
• 1292802-53-9 C₂₈H₃₃FN₆O 
• 1257902-26-3 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methyl-2-(methylthio)pyrimidine-4-carboxamide 
• 1257902-29-6 2-cyclopropyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methylpyrimidine-4-carboxamide 
• 1257902-30-9 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-5-methoxy-2,6-dimethylpyrimidine-4-carboxamide 
• 1257902-24-1 2-tert-butyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methylpyrimidine-4-carboxamide 
• 1257902-23-0 6-tert-butyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-2-methylpyrimidine-4-carboxamide 
• 1257902-22-9 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-isopropyl-2-methylpyrimidine-4-carboxamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.

Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives subs

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and

Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Pyrimidine usually has good pharmacokinetic properties as a drug substance and considerable efforts have been devoted to develop pyrimidine derivatives into drug candidates. Arylpiperazine-containing pyrimidine 4-carboxamide derivatives were synthesized and evaluated for binding to serotonin receptors and transporter. Pyrimidine derivatives showed good antidepressant activity in FST (forced swimming test) animal model and also displayed no appreciable inhibitory activity against hERG channel blocking assay. Herein SAR studies of pyrimidine derivatives targeting serotonin receptors and transporter will be disclosed.

Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof

The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represente