938307-34-7

Basic information

• Product Name: 3-[4-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-1-YL]-PROPYLAMINE
• Synonyms: 3-[4-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-1-YL]-PROPYLAMINE
• CAS NO: 938307-34-7
• Molecular Formula: C₁₅H₂₅N₃
• Molecular Weight: 247.3791
• Mol File: 938307-34-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[4-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-1-YL]-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-1-YL]-PROPYLAMINE(938307-34-7)
• EPA Substance Registry System: 3-[4-(2,3-DIMETHYL-PHENYL)-PIPERAZIN-1-YL]-PROPYLAMINE(938307-34-7)

Safety Data

• Hazardous Substances Data: 938307-34-7(Hazardous Substances Data)

Usage

Class

Piperazine derivative

Structure

Piperazine ring with propylamine group and 2,3-dimethylphenyl group attached

Uses

Building block in synthesis of pharmaceuticals and agrochemicals
Potential applications in medicinal chemistry for developing CNS-targeting drugs
Reagent in chemical research
Intermediate in production of other organic compounds

Upstream product

• 1013-22-5 1-(2,3-dimethylphenyl)piperazine 
• 1220831-49-1 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione 

Downstream Products

• 1292802-40-4 C₂₈H₃₄N₆O 
• 1292802-53-9 C₂₈H₃₃FN₆O 
• 1257902-26-3 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methyl-2-(methylthio)pyrimidine-4-carboxamide 
• 1257902-29-6 2-cyclopropyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methylpyrimidine-4-carboxamide 
• 1257902-30-9 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-5-methoxy-2,6-dimethylpyrimidine-4-carboxamide 
• 1257902-24-1 2-tert-butyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-methylpyrimidine-4-carboxamide 
• 1257902-23-0 6-tert-butyl-N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-2-methylpyrimidine-4-carboxamide 
• 1257902-22-9 N-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propyl)-6-isopropyl-2-methylpyrimidine-4-carboxamide 
• 1240266-82-3 C₂₈H₃₈N₄O*ClH 
• 1044529-25-0 Z₀₆₆-0150 
• 1044529-66-9 C₂₃H₂₈N₆O₂ 
• 1044529-21-6 C₂₂H₂₇N₇O₂ 
• 1044529-58-9 C₂₂H₂₇N₇O₂ 

Relevant articles and documents

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Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.

Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Arylpiperzine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated as novel antidepressant compounds. The various analogues were efficiently prepared and bio-assayed for binding to 5-HT2A, 5-HT2C receptor, and

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