938443-21-1

Basic information

• Product Name: 4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine
• Synonyms: 4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine;Pyrido[2,3-d]pyriMidine, 2,7-dichloro-4-(4-Morpholinyl)-
• CAS NO: 938443-21-1
• Molecular Formula: C₁₁H₁₀Cl₂N₄O
• Molecular Weight: 285
• Mol File: 938443-21-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 428.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.497g/cm3
• Refractive Index: 1.656
• Storage Temp.: 2-8°C
• PKA: 1.69±0.30(Predicted)
• CAS DataBase Reference: 4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine(938443-21-1)
• EPA Substance Registry System: 4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine(938443-21-1)

Safety Data

• Hazardous Substances Data: 938443-21-1(Hazardous Substances Data)

Usage

General Description

4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)morpholine is a chemical compound that belongs to the class of pyrimidine derivatives. It consists of a dichloropyrido[2,3-d]pyrimidin-4-yl group attached to a morpholine ring. 4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)morpholine is commonly used in pharmaceutical research as a potential drug candidate due to its diverse biological activities. It has been studied for its potential antineoplastic and antihypertensive properties, as well as its ability to inhibit protein kinases. Additionally, 4-(2,7-dichloropyrido[2,3-d]pyrimidin-4-yl)morpholine has been investigated for its potential role in the treatment of various diseases and conditions, making it an important target for further research and synthesis of related compounds.

InChI:InChI=1/C11H10Cl2N4O/c12-8-2-1-7-9(14-8)15-11(13)16-10(7)17-3-5-18-6-4-17/h1-2H,3-6H2

Upstream product

• 58584-92-2 2-amino-6-chloronicotinic acid 
• 938443-19-7 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 64321-24-0 2-amino-6-chloro-pyridine-3-carboxamide 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 110-91-8 morpholine 
• 938443-20-0 2,4,7-trichloropyrido[2,3-d]pyrimidine 

Downstream Products

• 938440-64-3 KU-63794 
• 938443-29-9 7-(3-chloromethyl-4-methoxy-phenyl)-2-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidine 
• 1424432-35-8 C₂₆H₃₄N₆O₃ 
• 1424432-36-9 C₂₅H₃₂N₆O₂ 
• 1424432-37-0 C₂₆H₃₄N₆O₂ 
• 938443-23-3 7-chloro-2-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidine 

Relevant articles and documents

Pyridine and miazines mTOR inhibitors

The invention belongs to the technical field of medicines, and particularly relates to a pyridopyrimidine mammalian target of rapamycin (mTOR) inhibitor which is shown as a general formula (I), pharmaceutically acceptable salts and stereoisomers thereof, and deuterated pyridopyrimidine mammalian mTOR inhibitors, wherein Z, Z, Z, R, R, R, X and W are defined in the specifications. The invention also relates to preparation methods for the compounds, medicinal inhibitors and medicinal compositions which contain the compounds, and the application of the compounds to preparation of medicines for treating and/or preventing post-transplant lymphoproliferative diseases which have response to inhibition of mTOR activity.

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity.

PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS

There is provided compounds of formula (I), which are suitable for the treatment of cancer.