93861-39-3Relevant articles and documents
Atypical Carbapenem Antibiotics with Improved Activity Against Carbapenemase-Producing Acinetobacter baumannii
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, (2020/11/30)
The following invention deals with the design, preparation, evaluation, and use of carbapenem antibiotics with improved activity, relative to current commercially available carbapenem antibiotics, against infections involving multidrug resistant, carbapen
Process for preparing an enol silyl ether compound
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, (2008/06/13)
A process for preparing an enol silyl ether compound from a diazoacetoacetic acid ester having the general formula (IV): STR1 wherein R1 is a lower alkyl group having 1 to 6 carbon atoms, phenyl group, a substituted phenyl group, an aralkyl group or allyl group, and R2, R3 and R4 are the same or mutually different and each is a lower alkyl group having 1 to 6 carbon atoms, which comprises reacting a diazoacetoacetic acid ester having the general formula (I): STR2 wherein R1 is the same as defined above, with a trialkylsilyl chloride having the general formula (II): STR3 wherein R2, R3 and R4 are the same as defined above, in an inert solvent in the presence of an organic base and an alkali halide having the general formula (III): wherein M is an alkaline metal and X is bromine atom or iodine atom. The desired compound is useful as an intermediate for synthesis of carbapenem β-lactam antibiotics.
A simple method of preparing trimethylsilyl- and tert-butyldimethylsilyl-enol eters of α-diazoacetoacetates and their use in the synthesis of a chiral precursor to thienamycin analogs
Ueda,Roberge,Vinet
, p. 2936 - 2940 (2007/10/02)
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